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In rodent models, Sema has been shown to activate GLP-1 receptors in the hypothalamus, indirectly affecting TSH (thyroid-stimulating hormone) levels and downstream thyroid hormone regulation
Effect of two-year caloric restriction on bone metabolism and bone mineral density in non-obese younger adults: a randomized clinical trial
For some, this may feel like simple bloating, while others might notice pain, gassiness, or a stretched-out feeling in the abdomen
Yes, especially if you taper off gradually and combine it with exercise, mindful eating, and professional support
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