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Figure 1 In line with these observations, weight loss has emerged not only as a supportive strategy but also as a disease-modifying intervention in PsA ( Preclinical studies further suggest that GLP-1RAs may modulate key cytokine pathways implicated in psoriatic disease, including NF-B, IL-6, IL17, and IL23, while small clinical studies have reported improvements in skin disease severity in PsO ( This narrative review summarizes the current clinical evidence on GLP-1RAs in PsO and PsA and discusses future research directions aimed at evaluating their potential role in intercepting PsA development and improving outcomes in patients with complex immunometabolic profiles

Evidence-based lifestyle interventions, including weight loss and dietary modification, remain the cornerstone of management

The medication reduces LDL (bad) cholesterol by 515%, increases HDL (good) cholesterol, and lowers triglycerides by up to 20% in many patients

Resting Metabolic Rate (RMR) Measures how many calories your body burns at rest, helping personalise your nutrition plan