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Gradual dose increases are crucial for managing potential gastrointestinal side effects

Beyond traditional labs, emerging biomarkers may offer additional insights into fibrosis progression or regression, though they are not yet standard in all practices

In animal models, acupuncture has an antioxidant effect by elevating the activity of enzymes such as SOD, GSH peroxidase, and CAT, and suppressing pro-oxidant markers including malondialdehyde and ROS [179, 180]

The cormorbidities often associated with HFpEF such as obesity, diabetes mellitus, and hypertension as well as the metabolic changes associated with them are known to induce a state of inflammation that affects cardiac metabolism, as well as coronary vascular injury and ischemia [5]