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In model experiments in pigs, they demonstrated that it was possible to completely protect infused GLP-1 against DPP-4 mediated degradation, and that this protection resulted in marked increase in the insulin response to glucose and GLP-1 (102)
Rybelsus is not commonly prescribed as a weight loss drug
Manufacturer copay cards and patient assistance programs exclude uninsured self-pay patients by design
We still dont know why people with diabetes (and obesity) dont lose as much weight compared with obesity without diabetes (as Drucker and I discussed in the companion podcast)
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