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Q.et al (2019)
Brain Sci 12:790 Bohnen NI et al (2022) Cholinergic system changes in Parkinsons disease: emerging therapeutic approaches
A previous study has shown that despite reducing lipid oxidation, LA supplementation decreases hepatic fat content and the activity and mRNA expression levels of lipogenic enzymes (acetyl-CoA carboxylase [ACC], FAS, ATP-citrate lyase [ACLY], and PK) in the livers of rats fed a diet with 10% fat content, in which fish oil was replaced by vegetable oil to different proportions (20% and 100%), and another study (sesamin and LA) found the same
3H), suggesting a dose-dependent effect, potentially due to excessive ROS scavenging at higher concentrations, which may impair the ROS-dependent signaling required for IL-1 induction
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