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These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks
Copper toxicity considerations Copper toxicity from GHK-Cu is extremely unlikely at standard doses but remains a theoretical concern worth understanding
Huang T, et al
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