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This pro-oxidant effect is especially relevant in malignant cells, which often already exist under elevated basal oxidative stress
The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time
Lim EJ, Ahn YC, Jang ES, Lee SW, Lee SH, Son CG
And then if you push it up even higher than that and it gets even worse
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