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The vitamin B12 is included to help prevent the B12 deficiency that GLP-1 medications can sometimes cause through reduced food intake and altered gastric acid production

Zepbound, Wegovy, Oral Wegovy, and Foundayo are all FDA-approved, and many insurance plans cover them when prescribed for weight management or a related condition such as obesity, high blood pressure, or sleep apnea

Ipamorelin is associated with improved cognitive skills, memory, pain relief, and internal body temperature regulation along with growth and muscle development

There is also a class-related warning about thyroid tumors (common to all GLP-1s) based on animal studies, though no such cases were reported in retatrutide trials so far