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Environmental factors, including mercury exposure and iron levels, can also interact with genetics
View on PubMed Raun K, Hansen BS, Johansen NL, et al
Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]
Our study extends the understanding of this pathway, linking the heightened enzymatic response to improved regenerative outcomes, a connection that has been previously suggested but not empirically validated in the context of tracheal reconstruction
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