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Hemolytic anemia and metabolic acidosis: think about glutathione synthetase deficiency
The evolutionary history was inferred by using the Maximum Likelihood method based on the JTT (Jones Taylor-Thornton) matrix-based model ( S.cerevisiae and 6 from S.bacillaris FRI751 and PAS13
Through conjugation reactions, glutathione binds to toxins, drugs, and metabolic byproducts, transforming them from fat-soluble compounds that accumulate in tissues into water-soluble forms that can be easily eliminated through urine and bile
IGF-1 signaling and aging [PMID: 15582293] Laboratory literature summary: IGF-1 signaling and aging
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