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Phase I detoxification involves the cytochrome P450 enzyme system, which breaks down fat-soluble toxinssuch as pharmaceutical medications, heavy metals, mold mycotoxins, and metabolic wasteinto intermediate compounds
We note, however, that human studies are controversial on this point
That 6+ percentage point gap is clinically meaningful
These categories should not be merged into a single conclusion because each has distinct experimental controls, sources of bias, and interpretive limits
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