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B12 is a water-soluble vitamin, meaning your body will naturally excrete any excess
In naturally aged mouse models (1820 months old), daily oral administration of 5-amino-1mq capsules for 12 consecutive weeks significantly reduced NNMT activity and increased NAD+ levels in various tissues (liver, kidney, adipose tissue), along with markedly elevated expression of SIRT1 and SIRT3 proteins
The causes can be broadly categorised into exogenous (external) and endogenous (internal) factors, with the latter being of greater clinical significance
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