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MC1R receptor variants in very fair-skinned individuals are less responsive to melanocortin signaling, requiring more sustained stimulation to switch from pheomelanin to eumelanin production
Materials and methods Animals Adult female Sprague Dawley rats ( n = 68), 90100 days of age were purchased from Charles River Laboratories (Wilmington, MA, United States)
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As we show below, not all trials report their demographic characteristicsfurther work to improve the level and quality of reporting is still needed
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