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It circulates at relatively high concentrations when you're young, around 200 ng/mL in your 20s , and drops steadily with age, reaching roughly 80 ng/mL by your 60s

Results from a phase 1 trial have supported further clinical evaluation with a dose-dependent WL up to 14.5% with AMG133 compared to 1.5% with placebo by day 85 [59]

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