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Description

We find that KMT2A-r leukemia is highly sensitive to MR and show a profound impact of MR on the metabolome and epigenome

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Our results identify the methionine cycle as a targetable vulnerability in KMT2A-r leukemia, which may increase the efficacy of epigenetic targeting agents

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Key Points Levels of glutathione within the cells and mitochondria are highly associated with health and longevity, and its deficiency is associated with loss of function with aging and many chronic diseases (including depression, anxiety, Alzheimers, Parkinsons, heart disease, and even cancer) Research over the last several years has illustrated a positive relationship between glutathione and vitamin D, with higher vitamin D levels related to higher glutathione levels

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