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In addition, dietary flavones promote the dissociation of NRF2 from Kelch-like ECH-associated protein 1 (Keap1) through two mechanisms: PKC-mediated phosphorylation of NRF2 and P62-mediated autophagic degradation of Keap1 [20]
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Jardiance also met the trials secondary endpoint, showing a 14% reduction in the risk of first and recurrent hospitalization compared to placebo, a result that was deemed significant
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