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Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity
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After the macrophages ingest MSU through the phagocytic pathway, NLRP3 inflammasome assembly and activation are triggered, and the generated complex consists of NLRP3, the adaptor protein apoptosis-related cyclin-like protein (ASC), and caspase-1 (53)
It may act as a trigger for localized cell death (HR) but also as a rapid signal for induction of antioxidative defenses
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