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The ratio of GSH to GSSG within cells is often used as a marker for cellular oxidative stress, with a higher ratio indicating a more reduced (and less stressed) cellular environment
B12 does not function as a stimulant like caffeine
There is no report of its occurrence in archaea which indicates that melatonin originated in bacteria [11] most likely to prevent the first cells from the damaging effects of oxygen in the primitive Earth's atmosphere
Proc Natl Acad Sci 89:444448 Kolesnik B, Palten K, Schrammel A, Stessel H, Schmidt K, Mayer B, Gorren AC (2013) Efficient nitrosation of glutathione by nitric oxide
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