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Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects

When the body is subjected to a severe biological triggersuch as the SARS-CoV-2 virus, Epstein-Barr Virus (EBV) reactivation, or severe physical traumathe immune system launches a massive inflammatory response

Many classes have been recognized so far, some of them with multiple members which may share sequence identities around 40%

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