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One can also determine a quantal dose-response curve for the therapeutic effect of a drug to generate a median effective dose ( ED 50 ), the concentration of drug at which 50% of the population will have the desired response, and a quantal dose-response curve for lethality by the same agent

However, benefits vary from person to person, and results are not permanent

60,91,101106 Topical Use of Estrogen and Estrogen Analogs There are other indications for treatment of aging skin without the use of systemic estrogen or other SERMs