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Avoid vigorous agitation, repeated freeze-thaw exposure, and unnecessary environmental exposure during handling

399,462 A pancancer whole-genome sequencing (WGS) study revealed that metastatic tumors frequently evolve from dominant subclones in the primary lesion, displaying higher clonality and lower intratumoral heterogeneity

The TCA cycle Following pyruvate entry into the mitochondria, pyruvate is metabolized in the TCA cycle to generate NADH and FADH2 to fuel the electron transport chain but also metabolic intermediates for biosynthesis and NADPH production

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