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( e ) Multiple linear regression for weight loss on semaglutide with predictors: 1 (% of AP viral expression) and 2 (% of NTS viral expression) (ns: not significant)
This dual mechanism explains their effectiveness not only in glycemic control but also in weight management
- Mechanistically, they propose semaglutide reprograms chondrocyte energy handling, shifting from glycolysis toward oxidative phosphorylation via the GLP-1R, AMPK, PFKFB3 axis
J Musculoskelet Neuronal Interact 21:142148 Cheng Y, Liu P, Xiang Q, Liang J, Chen H, Zhang H, Yang L (2022) Glucagon-like peptide-1 attenuates diabetes-associated osteoporosis in ZDF rat, possibly through the RAGE pathway
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