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Nonetheless, 2-DG is ineffective as a single agent to exert anticancer effects, including in clinical trials related to pancreatic and prostate cancer [84, 85]
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Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups
These challenges often correlate with high plasma protein binding, slow tissue distribution, and drug-drug interaction risks
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