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Am Fam Phys 70:19351944 Park HR, Lee JM, Moon HE, Lee DS, Kim BN, Kim J, Kim DG, Paek SH (2016) A Short review on the current understanding of autism spectrum disorders

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Hormonal therapy resistance Primary endocrine resistance in breast cancer is often associated with the loss of estrogen receptor (ER) expression, while the aberrant activation of bypass signaling pathways and mutations in the gene encoding ER constitute key mechanisms of acquired resistance (Fig

However, questions remain regarding long-term effectiveness, sex differences, brain-specific mechanisms, and safety in people with severe substance dependence