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Four-Octyl Itaconate Protects Chondrocytes against H(2)O(2)-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling

All therapies are reviewed for medical appropriateness and provided under clinical oversight in accordance with applicable state and federal requirements

The glutamate-cysteine ligase catalytic subunit (Gcl-c), the main controlling step of GSH synthesis is less expressed in mice overexpressing PGC-1 at basal conditions