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In mice fed Se deficient diets, testicular atrophy, reduced diameter of the seminiferous tubules, osseous metaplasia, and reduced spermatogenic activity were observed: no mitotic activity in spermatogonia, reduced the number of spermatogenic cell lines (including stem cells, pachytene spermatocytes, spermatids, and maturing sperms), and higher rates of abnormal morphology of sperm were found without difference in chromosomal abnormalities in spermatocytes (85, 100)

Potential Side Effects While generally well-tolerated , potential side effects include: Swelling and bruising at injection sites Temporary redness or tenderness Mild discomfort during or after treatment Rare cases of skin irritation These effects typically resolve within 48 hours

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Since LC is still used by the athletes [9, 10], the aim of this systematic review is to evaluate the effect of prolonged LC supplementation on metabolism/metabolic changes in healthy human subjects