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This suggests the dual mechanism might provide additional appetite control beyond GLP-1 alone
However, landmark cardiovascular and kidney outcome trials of GLP-1RAs excluded T1D populations 6,7
Under normal circumstances this does not occur, since GSH, in conjunction with the enzyme glutathione peroxidase (GSH-Px), rapidly inactivates these compounds
The incretin hormone GLP-1 and mechanisms underlying its secretion
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