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An increased risk of NAION was noted in semaglutide users at 2 years (HR 2.39), 3 years (HR 2.44), and 4 years (HR 2.05) after treatment initiation
Clinical hyperandrogenism includes hirsutism assessed by modified Ferriman Gallway score with a level 6, acknowledging that self-treatment is common and can limit clinical assessment
Wadden, PhDand funded by Novo Nordisk, the maker of semaglutidefound that GLP-1 users without known psychopathology werent any more likely to develop depression or suicidal thoughts or actions than controls
Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes
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