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It is characterized by severe IR, acanthosis nigricans and hyperandrogenism usually with more relevant clinical features in females in in the absence of obesity or lipodystrophy (1)
The PG gene consists of six exons and five introns, and the active form, GLP-1 (736 amide or 737), functions as a potent incretin
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If intake is not controlled externally, central obesity results from these behaviors combined with a low metabolic rate and decreased activity level (that result in a decreased total caloric requirement) (Figure 2)
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