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Description

558 In the DiscovEHR human genetics study, truncated loss-of-function variant in hydroxysteroid 17-dehydrogenase 13 ( HSD17B13 rs72613567: TA), a lipid droplet-associated protein that is enriched in liver and hepatocyte with retinol dehydrogenase activity, was found to associate with decreased levels of ALT and AST and improved liver histology of NASH