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While mice and rats do not vomit, GLP-1R agonism induces emesis in the musk shrew and is associated with an increase in cFOS staining in the AP, nucleus of the solitary tract (NTS), DMH, VMH, lateral hypothalamus (LH), and PVH that is blocked by GLP-1R antagonism (77)

When BPC-157 is used in ex-vivo or cell culture systems, investigators still follow biosafety guidance related to handling human or animal tissues, disposing of biological waste, and documenting any unexpected findings

Mojca Jensterle Sever of the University of Ljubljana, is that obesity is still perceived as a lifestyle disease. But because obesity is a disease that requires clinical intervention to provide meaningful benefits, medications should be considered in certain individuals