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This combination has been explored for its role in appetite suppression through monoamine modulation and support of synaptic plasticity

Dosage varies based on the condition being treated and patient needs

In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/P)-induced Parkinsons disease model mice, MPTP/P injection increased the ratio of Bax/Bcl-2 and the expression of caspase-3 in the hippocampus, while berberine administration reversed these effects ( In addition, animal experiments and cell experiments have confirmed that berberine reduces the levels of extracellular and intracellular A, increases the levels of LC3-II, Beclin-1, hVps34 and cathepsin-D, and reduced the levels of P62, Bcl-2, amyloid precursor protein (APP), and beta-secretase 1 (BACE1)

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