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Cocaine- and Amphetamine-Regulated Transcript, CART The cocaine- and amphetamine-regulated transcript (CART) peptides are neuroendocrine peptides involved in feeding behavior, drug reward systems, stress, cardiovascular functions, and bone remodeling
As discussed in our web page on prostaglandins, COX-2 is induced in endothelial and epithelial cells in response to a variety of stimuli, and aspirin acetylates the enzyme to switch it from prostanoid biosynthesis to that of 15 R -HETE (rather than the S enantiomer)
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