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ROS participate in this process by modulating signal transduction pathways that promote tyrosine phosphorylation, a key event in sperm activation ( In addition to lipid peroxidation, oxidative stress induces protein oxidation, which affects the function of key proteins involved in sperm motility and structure ( Oxidative stress in spermatozoa can originate from both internal and external sources
IGF1R is linked to various cytoplasmic second messenger molecules including the RAS-MAPK and PI3K signaling networks
BioMed Res
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