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[1] [4] Clinical trials have documented modest increases in resting heart rate (typically 2-5 beats per minute) with semaglutide

Unlike older off-patent medicines such as metformin, there is commercial incentive to test newer treatments such as GLP-1 agonists, a rapidly expanding class now dominated by Ozempic, known chemically as semaglutide, and Lillys Mounjaro, with other players working on a dozen potential new treatments

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The blend therefore acts on two of the three levers at once pushing the accelerator (GHRH receptor) while simultaneously easing the brake (via the ghrelin pathways functional antagonism of somatostatin tone)