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In this regards, SODs are classified into three forms and these include (i) Fe-SOD which is commonly found in prokaryotes and chloroplasts of some plants (ii) Mn-SOD which is present in prokaryotes and mitochondria of eukaryotes and (iii) Cu/Zn-SOD is predominant in eukaryotes and more distributed, localized basically in cytosol but also found in chloroplasts and peroxisomes.25, 26 The various isozymes of SOD are encoded by different genes
Over 40 years of research and clinical use have established that it is well tolerated with minimal adverse effects at recommended doses
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