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Preclinical studies have demonstrated that antibiotic treatment induces gut dysbiosis-marked by reduced alpha diversity, a decreased Firmicutes/Bacteroidetes ratio, depletion of beneficial genera, and enrichment of pro-inflammatory taxa (Tejkalov et al., 2023

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Whilst rare, cases of bacteraemia and fungaemia have been reported in immunocompromised patients taking probiotics

Note that domperidone has cardiac risks (including QT prolongation) and is restricted to short-term use, while metoclopramide carries a risk of movement disorders and should only be used for short courses