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Waist Circumference Reduction: Reduction in waist circumference from baseline, which is an indirect measure of visceral fat and is associated with a lower risk of cardiovascular comorbidities

First, pre-existing conditions in those organ systems may represent contraindications or risk factors that affect whether GLP-1 therapy is appropriate for you

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In comparison with naturally occurring receptor ligands, retatrutide has lower potency at the human glucagon and GLP-1 receptors, at approximately 0.3- and 0.4-fold, respectively, while showing markedly greater potency at the human GIP receptor, at about 8.9-fold