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That clinical context matters when patients ask whether medication is really necessary or whether lifestyle changes alone are sufficient
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Acute treatment of diet-induced obese mice with labelled semaglutide has been shown to allow the drug to access circumventricular organs that lack a substantial blood brain barrier, including the area postrema (AP), median eminence (ME), vascular organ of the lamina terminalis (OV), and subfornical organ (SFO) (33)
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OSA is associated with hypertension, arrhythmias, stroke, T2D, MASLD, and HFpEF, and independently increases cardiovascular and all-cause mortality
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