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Increased expression of the immediate response gene, early growth response gene-1 (egr-1), was shown in Caco-2 cells in vitro (Tkalcevic et al., 2007)
Results observed in one study or experimental model should not be expected in every research setting
This activation of NAD+ then supports SIRT1 pathways, which are crucial for mitochondrial function, fat oxidation, and overall metabolic flexibility
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