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Dham D, Roy B, Gowda A, Pan G, Sridhar A, Zeng X, et al

Based on available clinical data, retatrutide produced significantly greater weight loss (-24.2% at 48 weeks) than semaglutide (-16.0% at 68 weeks) in their respective trials

Logically, this leads to a decline in the protective function, which in turn increases oxidative stress

Glossary GLP-1 Glucagon-like peptide-1 GLP-1R GLP-1 receptor GLP-1Ras GLP-1R agonists DPP4 Dipeptidyl peptidase 4 GRPP Glicentin-related pancreatic polypeptide cAMP Cyclic adenosine monophosphate T2DM Type 2 Diabetes Mellitus PKA Protein Kinase A RGNEF4 Rap Guanine Nucleotide Exchange Factor 4 IP3 Inositol triphosphate pathway DAG Diacylglycerol CNS Central Nervous System BBB Blood Brain Barrier AD Alzheimers Disease PD Parkinsons Disease ROS Reactive Oxygen Species BDNF Brain-Derived Neurotrophic factor LTP Long Term Potentiation Ex-4 Exendin-4 MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine CVOTs CV outcome trials CRP C-reactive protein SCALE Satiety and Clinical Adipose Liraglutide Evidence STEP Semaglutide Treatment Effect in People with Obesity BMI Body Mass Index VLDL Very low-density lipoprotein LDL Low-density lipoprotein ApoB48 Apolipoprotein B48 EAT Epicardial adipose tissue DPP-4i Dipeptidyl peptidase-4 inhibitors SGLT-2i Sodium-glucose cotransporter-2 inhibitor RGCs Retinal Ganglion Cells IOP Intraocular pressure DR Diabetic Retinopathy GDM Gestational Diabetes Mellitus PAI-1 Plasminogen activator inhibitor type 1 VAM Vascular adhesion molecule PCOS Polycystic ovarian syndrome FH Functional hypogonadism References 1 GraafCdDonnellyDWoottenDLauJSextonPMillerMet al