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Mild menstrual changes are common and usually settle within 23 months of starting the medication
Higher levels of oestrogen can contribute to heavier, more painful periods, and when combined with obesity-related inflammation, this can exacerbate endometriosis pain
Why Researchers Choose Semaglutide Over Dual or Triple Agonists Versus Tirzepatide (GLP-1/GIP Dual): Tirzepatide adds a second pathway (GIP) that improves insulin sensitivity and may moderate gastrointestinal side effects, producing greater total weight loss (~20-22% vs ~15-17%)
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