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Menzies V, Starkweather A, Yao Y, Thacker LR 2nd, Garrett TJ, Swift-Scanlan T, et al

GLP1/E improves metabolic and gonadal traits in a PCOS model of ovarian dysfunction We next assessed the metabolic, gonadal, and hormonal effects of the intervention with equivalent doses (10 nmol/kg) of GLP1, E, or GLP1/E in PNA mice, which retain ovulatory capacity albeit with clear dysregulation of ovarian cyclicity

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Systemic reviews in 2025 still classify BPC157 as investigational, stressing that chronicuse safety in humans is unknown