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While current therapies are often effective during initiation, they tend to lose efficacy as time passes and only provide symptom control without addressing the underlying progressive nature of the disease

It occurs in almost every cell in the body though its intensity varies according to the site: energy-intensive organs such as the kidneys, liver and the heart especially, contain many mitochondria and are therefore hotbeds of production

Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans