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Going by lab values, when thyroid-stimulating hormone (TSH) is above 4.5 and free thyroxine (T4) is below 0.8, someone has overt hypothyroidism 5 6

Among patients with UC, those treated with GLP1RA had lower rates of corticosteroid use (39.9% vs 76.0%), emergency department visits (41.9% vs 52.7%), hospitalization (30.6% vs 55.8%), intestinal resection (17.8% vs 53.9%), and mortality (5.8% vs 10.9%)

Fluid retention and oedema a known adverse effect of tesamorelin, which could be compounded by broader metabolic shifts

As hormone levels fluctuate, collagen production often declines, leading to a loss of firmness and elasticity