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The inflammatory response and ROS accumulation following injury and irritation naturally associate tissue regeneration and remodeling processes with ferroptosis, which we comprehensively address below
2.3.2 FSP1/CoQ10/NADPH and GCH1/BH4/DHFR axis In a tumor xenograft mouse model, GPX4-ko/FSP1-ko tumor growth was inhibited, while GPX4-ko tumors grew normally, indicating that the FSP1/CoQ10/NADPH system protects cells from ferroptosis induced by GPX4 inhibition or knockout, supplementing the loss of GPX4 with an antioxidant enzyme catalytic system (Bersuker et al., 2019)
If months of daily supplementation have not moved your labs, absorption is the likely bottleneck
10.1016/s1388-1981(00)00151-7 91 KatafuchiT.MakishimaM
