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Relevant studies have also investigated the role of TWIST in regulating E-cadherin transcription and p16 expression, revealing that HIF-TWIST-polycomb signaling participates in the development and metastasis of PC [329]
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A sensitized high-throughput screen was used to identify 5-fluoropyrimidine-based GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nanomolar potency
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