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Mitochondrial GR is essential for: Protecting the electron transport chain components from oxidative damage Maintaining mitochondrial DNA integrity against oxidative lesions Supporting ATP production by preserving mitochondrial membrane potential Preventing mitochondrial-initiated apoptosis triggered by excessive oxidative stress Facilitating mitochondrial glutathione transport and utilization The mitochondrial glutathione system is particularly critical in neurons and other cells with high energy demands, where mitochondrial dysfunction can have catastrophic consequences

Long-term safety data beyond 90 days is limited even for the individual compounds

A Pilot Study on Aging Skeletal Muscle Mass and Function

From their beginnings as a treatment for type 2 diabetes, GLP-1 receptor agonists such as semaglutide and tirzepatide have seen an explosion in use, most popularly for weight loss