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Viral proteins as well as host damage-associated molecular patterns, that accumulate following cellular stress during viral infection, were linked to TLR4 activation, with uncontrolled TLR4 activation being associated with severe disease (Olejnik et al., 2018)

In patients with Neurofibromatosis type 1 (NF1), malignant transformation of a pre-existing plexiform neurofibroma may be indicated by a sudden increase in size, new-onset pain, or neurologic deficits

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