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Studies and adverse event reports have associated GLP-1 medications with an increased risk of non-arteritic anterior ischemic optic neuropathy (NAION), which can lead to vision loss

Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study

It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

Long-term health benefits beyond weight loss Medications like semaglutide and tirzepatide can take some of the struggle out of losing weight and maintaining that change